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A new approach towards the impedimetric biosensing system
Au-Minecraft
A new approach towards the impedimetric biosensing system
The Au-Minecraft is the system that will allow for more precise electrochemical detection of selected biochemical interactions of proteins, enzymes, and DNA. This task will be possible thanks to the innovative use of gold nanostructures, appropriately surface-modified to identify host-guest interactions. The project will examine and determine how changes in the self-organization of gold nanostructures will affect charge transfer in the diffusion areas. The Au-Minecraft will detect impedance parameters resulting from changes in the heterogeneity level at the electrode surface, caused by the occurrence of specific intermolecular interactions and intentional, controlled disturbance of the sensor surface geometry. The project was financed by the National Science Centre in OPUS call (2020/37/B/ST7/03262).
Members
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Prof. Jacek Ryl
Principal Investigator - GUTAssociate Professor at Institute of Nanotechnology and Materials Engineering, GUT. Materials engineer and applied electrochemistry specialist, dedicated to impedimetric studies of the biosensing nanosystems, signal processing, and physicochemical studies.
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Dr Sylwia Bloch
InvestigatorAssistant Professor in the Laboratory of Phage Therapy, IBB PAS. Her main research interests are focused on phage biodiversity, regulation of processes occurring during phage development. In project dedicated to studying receptor/co-receptor interactions
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Miss Karolina Sapiega
MSc student - scholarM.Sc. student of biomedical engineering at GUT. Investigating electrochemistry of gold nanoarchitecture and gold-TiO2 heterojunction for biosensing applications, particularly with transparent transducers.
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Miss Klaudia Prusik
MSc student - scholarM.Sc. student of Materials Engineering at GUT, specializing in photoactive materials and photocatalysis. Investigating AuNC heterojunctions and combined, opto-electrochemical (bio)sensor action
News
Resources
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Jacek Ryl, Pawel Slepski
6th International Symposium on Surface Imaging/Spectroscopy at the Solid/Liquid Interface
A new approach towards the impedance biosensing by multifrequency measurements
In this conference presentation, Jacek discussed how the utilization of Dynamic Electrochemical Impedance Spectroscopy in potentiodynamic or galvanostatic mode can be used for biosensing purposes, including flow injection tests and studies at charged up electrode surfaces surface heterogeneity changes, use for receptor evaluation, and more.
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Paweł Niedziałkowski, Paweł Ślepski, Joanna Wysocka, Joanna Chamier-Ciemińska, Łukasz Burczyk, Michał Sobaszek, Anna Wcisło, Tadeusz Ossowski, Robert Bogdanowicz, Jacek Ryl
Sensors and Actuators B: Chemical
Multisine impedimetric probing of biocatalytic reactions for label-free detection of DEFB1 gene: How to verify that your dog is not human?
In this work, we utilized for the very first time the DEIS for electrochemical sensing. The target of our study was the DEFB1 gene, which is unique to the human species. The analysis in a wide polarization range allowed us to find significant differences in the electric signal if DNA hybridization took place at the electrode surface, marking successful detection. Confirmation of the possibility to control frequency dispersion of capacitance in biosensing systems was the groundwork for our Au-Minecraft project.